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1.
Braz J Med Biol Res ; 49(10): e5310, 2016 Sep 29.
Artigo em Inglês | MEDLINE | ID: mdl-27706439

RESUMO

Although it is well known that physical training ameliorates brain oxidative function after injuries by enhancing the levels of neurotrophic factors and oxidative status, there is little evidence addressing the influence of exercise training itself on brain oxidative damage and data is conflicting. This study investigated the effect of well-established swimming training protocol on lipid peroxidation and components of antioxidant system in the rat brain. Male Wistar rats were randomized into trained (5 days/week, 8 weeks, 30 min; n=8) and non-trained (n=7) groups. Forty-eight hours after the last session of exercise, animals were euthanized and the brain was collected for oxidative stress analysis. Swimming training decreased thiobarbituric acid reactive substances (TBARS) levels (P<0.05) and increased the activity of the antioxidant enzyme superoxide dismutase (SOD) (P<0.05) with no effect on brain non-enzymatic total antioxidant capacity, estimated by FRAP (ferric-reducing antioxidant power) assay (P>0.05). Moreover, the swimming training promoted metabolic adaptations, such as increased maximal workload capacity (P<0.05) and maintenance of body weight. In this context, the reduced TBARS content and increased SOD antioxidant activity induced by 8 weeks of swimming training are key factors in promoting brain resistance. In conclusion, swimming training attenuated oxidative damage and increased enzymatic antioxidant but not non-enzymatic status in the rat brain.


Assuntos
Antioxidantes/metabolismo , Encéfalo/metabolismo , Terapia por Exercício/métodos , Estresse Oxidativo/fisiologia , Condicionamento Físico Animal/fisiologia , Natação/fisiologia , Animais , Antioxidantes/análise , Peso Corporal , Peroxidação de Lipídeos/fisiologia , Masculino , Malondialdeído/análise , Malondialdeído/metabolismo , Distribuição Aleatória , Ratos Wistar , Espécies Reativas de Oxigênio/metabolismo , Valores de Referência , Reprodutibilidade dos Testes , Espectrofotometria , Superóxido Dismutase/análise , Superóxido Dismutase/metabolismo , Substâncias Reativas com Ácido Tiobarbitúrico/análise , Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo , Fatores de Tempo
2.
Braz. j. med. biol. res ; 49(10): e5310, 2016. graf
Artigo em Inglês | LILACS | ID: biblio-951650

RESUMO

Although it is well known that physical training ameliorates brain oxidative function after injuries by enhancing the levels of neurotrophic factors and oxidative status, there is little evidence addressing the influence of exercise training itself on brain oxidative damage and data is conflicting. This study investigated the effect of well-established swimming training protocol on lipid peroxidation and components of antioxidant system in the rat brain. Male Wistar rats were randomized into trained (5 days/week, 8 weeks, 30 min; n=8) and non-trained (n=7) groups. Forty-eight hours after the last session of exercise, animals were euthanized and the brain was collected for oxidative stress analysis. Swimming training decreased thiobarbituric acid reactive substances (TBARS) levels (P<0.05) and increased the activity of the antioxidant enzyme superoxide dismutase (SOD) (P<0.05) with no effect on brain non-enzymatic total antioxidant capacity, estimated by FRAP (ferric-reducing antioxidant power) assay (P>0.05). Moreover, the swimming training promoted metabolic adaptations, such as increased maximal workload capacity (P<0.05) and maintenance of body weight. In this context, the reduced TBARS content and increased SOD antioxidant activity induced by 8 weeks of swimming training are key factors in promoting brain resistance. In conclusion, swimming training attenuated oxidative damage and increased enzymatic antioxidant but not non-enzymatic status in the rat brain.


Assuntos
Animais , Masculino , Condicionamento Físico Animal/fisiologia , Natação/fisiologia , Encéfalo/metabolismo , Estresse Oxidativo/fisiologia , Terapia por Exercício/métodos , Antioxidantes/metabolismo , Valores de Referência , Espectrofotometria , Superóxido Dismutase/análise , Fatores de Tempo , Peso Corporal , Peroxidação de Lipídeos/fisiologia , Distribuição Aleatória , Reprodutibilidade dos Testes , Espécies Reativas de Oxigênio/metabolismo , Malondialdeído/análise , Malondialdeído/metabolismo , Antioxidantes/análise
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